Thermo Fisher Scientific WNK1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat.

Target Information

WNK1 serine/threonine kinase is a member of the WNK subfamily and may regulate blood pressure by controlling sodium and chloride ion transport. Mutations in this gene are associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II.
WNK1 plays a key role in electrolyte homeostasis, cell signaling, survival, and proliferation. It acts as both activator and inhibitor of sodium- and potassium-coupled chloride cotransporters, respectively, and activates SCNN1A, SCNN1B, SCNN1D, and SGK1.
WNK1 localizes to the distal nephron, a kidney segment involved in salt, potassium, and pH homeostasis. Mutations in the WNK gene can lead to pseudohypoaldosteronism and neuropathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.