Thermo Fisher Scientific STAT5 beta Recombinant Rabbit Monoclonal Antibody (6P5T0)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Immunoprecipitation (IP)

0.5 µg-4 µg antibody for 200 µg-400 µg extracts of

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

6P5T0

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 600-787 of human STAT5B (P51692). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:STAT5 beta,uniProtId:P51692-1,ncbiNodeId:9606,antigenRange:600-787,antigenLength:787,antigenImageFileName:MA5-42707_STAT5_beta_P51692-1_Rabbit.svg,antigenImageFileNamePDP:MA5-42707_STAT5_beta_P51692-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.53 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2911848

Product Specific Information

Positive test controls include: K-562, Mouse thymus, Mouse heart, Rat heart, HeLa. The target is usually found in the following locations: Cytoplasm, Nucleus.

Immunogen sequence: KQQAHDLLIN KPDGTFLLRF SDSEIGGITI AWKFDSQERM FWNLMPFTTR DFSIRSLADR LGDLNYLIYV FPDRPKDEVY SKYYTPVPCE SATAKAVDGY VKPQIKQVVP EFVNASADAG GGSATYMDQA PSPAVCPQAH YNMYPQNPDS VLDTDGDFDL EDTMDVARRV EELLGRPMDS QWIPHAQS

Target Information

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.