Thermo Fisher Scientific Tau Recombinant Rabbit Monoclonal Antibody (6F5Z2)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive test controls: HeLa, SH-SY5Y, U-251MG
• Subcellular localization: Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, axon, cytoskeleton, cytosol

Immunogen sequence:
PKSPSSAKSR LQTAPVPMPD LKNVKSKIGS TENLKHQPGG GKVQIINKKL DLSNVQSKCG SKDNIKHVPG GGSVQIVYKP VDLSKVTSKC GSLGNIHHKP G

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus interacts with neural plasma membrane components, functioning as a linker between both structures. Tau localization determines axonal polarity within neurons.

Short isoforms provide cytoskeletal plasticity, whereas longer isoforms contribute to stabilization. In its hyper-phosphorylated form, Tau constitutes the major component of paired helical filaments (PHF), which form neurofibrillary lesions characteristic of Alzheimer’s disease (AD). Hyper-phosphorylation reduces microtubule binding, leading to destabilization and neuronal degeneration. Multiple kinases, including GSK-3β, PKA, cdk5, and casein kinase II, phosphorylate Tau. Hyper-phosphorylated Tau is also implicated in other neurodegenerative disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.