Thermo Fisher Scientific Cytohesin 3 Polyclonal Antibody
Cytohesin 3 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. Human 시료에 반응하며, 고순도 Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관하며, -20°C에서 안정적으로 저장 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CYTH3 (Accession O43739), corresponding to amino acid residues G182–P232 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852254 |
Product Specific Information
Antibody detects endogenous levels of total CYTH3.
Target Information
GRP1 (general receptor for phosphoinositides-1) contains a Pleckstrin homology (PH) domain and a Sec7 domain.
The PH domain binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), while the Sec7 domain catalyzes guanine nucleotide exchange of ADP-ribosylation factor (ARF) proteins.
GRP1 co-localizes with ARF6 and catalyzes GTP/GDP exchange on ARF6. It interacts with PtdIns(3,4,5)P3 localized to the plasma membrane and may function as a PtdIns(3,4,5)P3 receptor.
Additionally, GRP1 may regulate protein sorting and membrane trafficking through interaction with ARF, and may control cell adhesion through interaction with integrins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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