Thermo Fisher Scientific PPP1R1A Polyclonal Antibody
PPP1R1A 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot에 적합합니다. 인간 및 비인간 영장류 반응성을 가지며, 액상 형태로 제공되고 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PPP1R1A (Accession Q13522), corresponding to amino acid residues G128–V171 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2852258 |
Product Specific Information
Antibody detects endogenous levels of total PPP1R1A.
Target Information
Protein phosphatase inhibitor-1 (also designated inhibitor of protein phosphatase 1, IPP-1, and I-1) regulates phosphorylation of other proteins and is phosphorylated by cyclic AMP-dependent protein kinase at Threonine 35.
Cdk1, Cdk5, and MAPK mediate in vitro phosphorylation at Serine 67.
In striatal tissues, glutamate-dependent regulation of NMDA-type channels influences IPP-1 phosphorylation at Ser 67.
Localization and expression suggest discrete roles in brain development, independent of PP-1 regulation.
IPP-1 binds both phosphorylated and dephosphorylated PP-1 and modulates glycogen phosphorylase activity, contributing to hormonal control of glycogen metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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