Thermo Fisher Scientific SPRED1 Polyclonal Antibody
SPRED1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, 항원 친화 크로마토그래피로 정제되었습니다. 뇌 조직을 양성 대조군으로 권장하며 연구용으로 사용됩니다.
- 카탈로그번호
- PA520618
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 2.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide near the center of the human Spred1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at −20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157211 |
Product Specific Information
- Suggested positive control: Human brain tissue lysate
- PA5-20618 can be used with blocking peptide PEP-0738.
Target Information
The Ras-MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes; it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf.
Spred proteins have been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis.
Studies indicate that Spred1 and Spred2 expression levels are inversely correlated with tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting potential roles as prognostic factors and therapeutic targets in HCC.
Defects in this gene are associated with neurofibromatosis type 1-like syndrome (NFLS).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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