Thermo Fisher Scientific DDHD1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µL/mg of lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from the date of receipt.

Target Information

The DDHD1 gene encodes a member of the intracellular phospholipase A1 gene family. This cytosolic protein preferentially hydrolyzes phosphatidic acid and is partially localized to mitochondria. It plays a role in regulating mitochondrial dynamics.
Overexpression of DDHD1 causes mitochondrial fragmentation, while depletion results in elongated mitochondrial tubules. In male mice, deletion leads to fertility defects due to disrupted mitochondrial organization during spermiogenesis.
In humans, mutations in this gene are linked to hereditary spastic paraplegia (HSP), also known as Strumpell-Lorrain disease or familial spastic paraparesis (FSP), characterized by progressive weakness and spasticity of the legs.
Alternative splicing produces multiple transcript variants encoding different isoforms.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.