Thermo Fisher Scientific DDHD1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

This gene belongs to the intracellular phospholipase A1 gene family. The encoded protein preferentially hydrolyzes phosphatidic acid and is mainly cytosolic with partial mitochondrial localization. It plays a role in regulating mitochondrial dynamics.

Overexpression of this gene leads to mitochondrial fragmentation, while depletion causes elongation of mitochondrial tubules. Deletion in male mice results in fertility defects due to disrupted mitochondrial organization during spermiogenesis. In humans, mutations are associated with hereditary spastic paraplegia (HSP), also known as Strumpell-Lorrain disease or familial spastic paraparesis (FSP), characterized by progressive leg weakness and spasticity. Alternative splicing produces multiple transcript variants.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.