Thermo Fisher Scientific uPAR Monoclonal Antibody (109801)
Thermo Fisher Scientific의 uPAR 단클론 항체(109801)는 마우스 유래 uPAR을 특이적으로 인식하며, Western blot, Flow cytometry, Neutralization assay에 적합합니다. Rat IgG2a 형식의 항체로, Protein A/G 정제 및 동결건조 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | - |
| Flow Cytometry (Flow) | 2.5 µg per million cells | 1 publication |
| Neutralization (Neu) | Assay-Dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 109801 |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse uPAR isoform 1 (Leu24–Thr297) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608906 |
Product Specific Information
- In Western blots, this antibody does not cross-react with recombinant human uPAR.
- Reconstitute at 0.5 mg/mL in sterile PBS.
- Endotoxin level is <0.10 EU per 1 µg of antibody (LAL method).
Target Information
The urokinase-type plasminogen activator receptor (uPAR) is a key molecule regulating cell-surface plasminogen activation, playing roles in both normal and pathological processes.
The human PLAUR cDNA encodes 335 amino acids, including a 22-residue signal peptide and hydrophobic C-terminal region. It produces a glycosylated ~50 kDa protein anchored to the plasma membrane via a GPI linkage.
PLAUR (uPAR) associates with the carbohydrate-binding domain of SELL on neutrophil membranes, analogous to its interaction with β2 integrins. PLAUR-mediated calcium mobilization is SELL-dependent.
UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas, showing a 33-fold increase in advanced stages compared with normal tissue. UPAR expression correlates with recurrence and mortality, making it a potential prognostic marker for advanced endometrial cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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