Thermo Fisher Scientific ZDHHC16 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

ZDHHC16 (zinc finger, DHHC-type containing 16), also known as APH2, is a 377-amino-acid multi-pass membrane protein localized to the endoplasmic reticulum and containing one DHHC-type zinc finger. It exists as multiple alternatively spliced isoforms, interacts with c-Abl, and catalyzes the conversion of Palmitoyl-CoA and protein-cysteine to S-palmitoyl protein and CoA. Through its association with c-Abl, ZDHHC16 may be involved in regulating apoptosis. The gene encoding ZDHHC16 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Mutations in genes on chromosome 10 are associated with several disorders, including Charcot-Marie-Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2, and porphyria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.