Thermo Fisher Scientific USP28 Polyclonal Antibody

Thermo Fisher Scientific USP28 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:500–1:3,000
Publications: N/A

Product Specifications

Product Specific Information

• Recommended positive controls: A431
• Predicted reactivity: Mouse (100%), Rat (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26S proteasome are coupled to multiple copies of ubiquitin. Attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity.
Deubiquitination is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families:

1. Ubiquitin C-terminal hydrolases
2. Ubiquitin-specific processing proteases (USPs)
3. OTU-domain ubiquitin-aldehyde-binding proteins
4. Jab1/Pad1/MPN-domain-containing metallo-enzymes

Among these families, USPs are the most widespread. They release ubiquitin from conjugated proteins and contain conserved catalytic domains with Cys and His boxes, while their terminal extensions contribute to substrate recognition and localization.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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