Thermo Fisher Scientific Lymphotoxin beta Receptor Monoclonal Antibody (eBio3C8 (3C8)), eBioscience
Mouse LTβR 단백질을 인식하는 Rat IgG1 단일클론 항체로, Flow Cytometry에 적합. 높은 순도(>90%)와 낮은 응집(<10%)을 보유하며, PBS buffer에 0.09% sodium azide 포함. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Lymphotoxin beta Receptor Monoclonal Antibody (eBio3C8 (3C8)), eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 0.5 µg/test | View 3 publications |
| Functional Assay | - | View 1 publication |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio3C8 (3C8) |
| Conjugate | Unconjugated |
| Available Formats | Biotin, Functional Grade, PE, Request custom conjugation |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_467567 |
Product Specific Information
The antibody reacts with mouse lymphotoxin-beta receptor (LTBR). Expression of LTBR mRNA is strong in lung, liver, and kidney; moderate in heart and testes; weak in brain, thymus, spleen, and lymph nodes. The human receptor for the LT-alpha/LT-beta heterotrimer (LT-alpha1beta2) participates in immunologic reactions via cell-cell contact but does not bind TNFR1 or TNFR2. LTBR expression begins at day 7 of embryogenesis, suggesting a role in early development.
Applications Reported: Suitable for flow cytometric analysis.
Applications Tested: Tested on NIH/3T3 cells; optimal at ≤0.5 µg/test (100 µL final volume). Cell number should be empirically determined (10⁵–10⁸ cells/test). Titrate for best assay performance.
Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered
Target Information
The LTβR protein is a member of the TNF receptor family, expressed on most cell types except T and B lymphocytes. It binds the membrane form of lymphotoxin (LTα/LTβ complex) and plays a role in lymphoid tissue development and organization, as well as in apoptosis induction upon activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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