Thermo Fisher Scientific TSLP Receptor Monoclonal Antibody (eBio1A6 (1A6)), eBioscience
인간 TSLP 수용체를 인식하는 마우스 단클론 항체로, Flow Cytometry 및 Western Blot에 적합합니다. IL-7Rα와 복합체를 형성하여 TSLP 결합에 관여하며, 면역세포 활성화 연구에 유용합니다. 액상 형태로 4°C 보관, 0.09% sodium azide 함유.
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- 14-5499-xx (3개 옵션)
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카탈로그
3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TSLP Receptor Monoclonal Antibody (eBio1A6 (1A6)), eBioscience
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Flow Cytometry (Flow) | 0.5 µg/test | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a, lambda |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio1A6 (1A6) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2865111 |
Additional Formats
- APC (Cat. 17-5499-42)
- PE (Cat. 12-5499-42)
- PerCP-eFluor 710 (Cat. 46-5499-42)
- Super Bright 436 (Cat. 62-5499-42)
- Super Bright 600 (Cat. 63-5499-42)
- Super Bright 780 (Cat. 78-5499-42)
- Custom conjugation available on request
Product Specific Information
The eBio1A6 monoclonal antibody reacts with human thymic stromal-derived lymphopoietin receptor (TSLPR), a ~50 kDa protein similar to the common gamma-chain. TSLPR forms a high-affinity receptor complex with IL-7Rα (CD127) to bind TSLP. It is expressed by monocytes and CD11c⁺ dendritic cells, where TSLP binding induces Th2-attracting chemokines CCL17 and CCL22.
Activation of dendritic cells via TSLPR increases secretion of IL-4, IL-5, and IL-13, contributing to CD4⁺ T cell homeostasis. In mice, TSLPR deficiency alone does not affect lymphocyte numbers, but combined deficiency with the common gamma-chain reduces lymphocyte counts. The eBio1A6 antibody can cross-block another anti-human TSLPR antibody, 1D8.
Applications Reported: Flow cytometry and Western blotting (WB).
Applications Tested: Validated in flow cytometric analysis using human TSLPR-transfected Ba/F3 cells. Recommended ≤0.5 µg/test in 100 µL volume, with 10⁵–10⁸ cells/test. Optimize titration for best performance.
Purity: >90% (SDS-PAGE).
Aggregation: <10% (HPLC).
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Thymic stromal lymphopoietin (TSLP) drives dendritic cell maturation and activation, supports regulatory T cell selection, and maintains peripheral CD4⁺ T cell homeostasis. It also promotes B cell progenitor growth and differentiation to IgM⁺ stage. TSLP receptor (TSLP-R) binds TSLP with low affinity; co-expression with IL-7Rα forms a high-affinity, functional heteromeric complex that signals via STAT5 and is inhibited by SOCS-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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