Thermo Fisher Scientific FOXP3 Monoclonal Antibody (UMAB248), UltraMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, an additional desalting step is recommended (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

FOXP3 (Forkhead box protein 3) is a transcriptional regulator belonging to the forkhead/winged-helix family, conserved across mammals and essential for immune homeostasis.
It is highly expressed in CD25⁺CD4⁺ regulatory T cells, expressed at low levels in CD4⁺/CD25⁻ cells, and absent in CD4⁻/CD8⁺ T cells.
FOXP3 acts as a master regulatory gene and a key marker of regulatory T cells.
Mutations in FOXP3 cause immune dysregulation syndromes such as IPEX (immune dysfunction, polyendocrinopathy, enteropathy, X-linked) in humans.
In cancer research, FOXP3 expression is regulated by p53 in response to DNA damage in breast and colon cancer cells.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.