Thermo Fisher Scientific SIRT2 Recombinant Rabbit Monoclonal Antibody (SN70-04)
SIRT2 단백질을 표적하는 Thermo Fisher의 재조합 토끼 단클론 항체로, 높은 특이성과 민감도를 제공합니다. Western blot, ICC/IF, Flow Cytometry에 사용 가능하며, HEK293 세포에서 발현된 IgG 형 항체입니다. 일관된 품질과 동물 유래 성분이 없는 포뮬레이션을 제공합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SN70-04 |
| Immunogen | Synthetic peptide within Human SIRT2 aa 335–389 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809602 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select the best candidates for production.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
SIRT2 (Sirtuin 2) is a NAD-dependent deacetylase (NDAC) involved in gene silencing, cell cycle regulation, and DNA damage repair. It may act as a tumor suppressor in human gliomas and serve as a molecular marker for these cells.
SIRT2 also functions as a redox sensor regulating muscle gene expression in response to food intake and exercise, and is phosphorylated during mitosis (late G2 phase through cytokinesis).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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