Thermo Fisher Scientific RARA Recombinant Rabbit Monoclonal Antibody (SN0725)

Applications

Western Blot (WB)

• Tested Dilution: 1:50–1:2,000

Flow Cytometry (Flow)

• Tested Dilution: 1:50–1:100
• Publications: 1 publication available

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Specific antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
Advantages include:

• Improved specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to the larger rabbit immune repertoire

Target Information

RARA (Retinoic Acid Receptor Alpha) is a receptor for retinoic acid that binds as a heterodimer (with RXR) to DNA response elements, regulating gene expression in response to all-trans or 9-cis retinoic acid.

• In the absence of ligand, RXR-RAR heterodimers associate with corepressors, leading to chromatin condensation and transcriptional repression.
• Upon ligand binding, corepressors dissociate and coactivators are recruited, resulting in transcriptional activation.
• RARA is crucial for retinoic acid-induced germ cell development during spermatogenesis and contributes to skeletal growth and matrix homeostasis.
• It regulates gene expression via ligand-dependent recruitment of chromatin complexes containing KMT2E/MLL5 and mediates retinoic acid-induced granulopoiesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.