Thermo Fisher Scientific Cytokeratin 18 Monoclonal Antibody (RCK106)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA1-06327 detects cytokeratin 18 in human samples.
It has been successfully used in Western blotting, immunocytochemistry, immunohistochemistry, and flow cytometry.
The immunogen is cytokeratins derived from the human bladder carcinoma cell line T24.

Target Information

Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins and exists in combination with cytokeratin 8.
It is expressed in tissues from the gastrointestinal, respiratory, and urogenital tracts, as well as endocrine and exocrine tissues and mesothelial cells.
Cytokeratin 18 is primarily found in non-squamous epithelia and is present in most adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas.
Hepatocellular carcinomas express only cytokeratins 8 and 18. Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis.
Two transcript variants encoding the same protein have been identified.
Cytokeratin subtype expression patterns are increasingly used to distinguish epithelial malignancies.
Cytokeratin antibodies assist in tumor differential diagnosis via immunohistochemistry and are useful in cytopathology and flow cytometric assays.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.