Thermo Fisher Scientific CEACAM8 Polyclonal Antibody
Rabbit polyclonal antibody against human CEACAM8 (CD66b). Validated for WB and IHC(P) applications. Provides high specificity and affinity for cell membrane and surface detection. Suitable for research use in immune response and tumor studies.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within human CD66b (CEACAM8) amino acids 1–250 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913372 |
Product Specific Information
- Positive Control: U937 cell lysate, A431 cell lysate, Daudi cell lysate, Human colon cancer tissue, Human colon tissue
- Subcellular Location: Cell membrane, Cell surface
Target Information
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, part of the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in this cluster.
The encoded protein was initially identified in bile ducts as biliary glycoprotein and later recognized as a cell-cell adhesion molecule expressed on leukocytes, epithelia, and endothelia. It mediates cell adhesion via homophilic and heterophilic interactions with other subgroup proteins. The protein is involved in tissue differentiation, structural organization, angiogenesis, apoptosis, tumor suppression, metastasis, and modulation of immune responses. Multiple transcript variants exist, though not all are fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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