Thermo Fisher Scientific CEACAM8 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive Control: U937 cell lysate, A431 cell lysate, Daudi cell lysate, Human colon cancer tissue, Human colon tissue
• Subcellular Location: Cell membrane, Cell surface

Target Information

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, part of the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in this cluster.

The encoded protein was initially identified in bile ducts as biliary glycoprotein and later recognized as a cell-cell adhesion molecule expressed on leukocytes, epithelia, and endothelia. It mediates cell adhesion via homophilic and heterophilic interactions with other subgroup proteins. The protein is involved in tissue differentiation, structural organization, angiogenesis, apoptosis, tumor suppression, metastasis, and modulation of immune responses. Multiple transcript variants exist, though not all are fully characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.