Thermo Fisher Scientific SCN1A Polyclonal Antibody
Arabidopsis thaliana SCN1 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot에 적합하며 세포질 내 SCN1 단백질 검출에 사용. 항원 친화 크로마토그래피로 정제된 고순도 항체로 연구용으로만 사용 가능.
- 카탈로그번호
- PA5119799
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
- Positive Control: Arabidopsis thaliana tissue lysates
- Subcellular Location: Cytoplasm
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Plant |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within Arabidopsis thaliana SCN1 aa 1–240 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913371 |
Target Information
Epithelial sodium channels (ENaC) are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels.
These channels share structural similarity, possessing two intracellular termini, two transmembrane segments, and a large extracellular loop with a conserved cysteine-rich region.
There are three homologous isoforms of ENaC (alpha, beta, and gamma). ENaC in the kidney, lung, and colon is essential for sodium and fluid balance and mediates aldosterone-dependent sodium reabsorption in the distal nephron, thereby regulating blood pressure.
ENaC function is influenced by interaction with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.
Gain-of-function mutations in beta- or gamma-ENaC can cause Liddle’s syndrome (hypertension), while loss-of-function mutations in alpha- or beta-ENaC can lead to pseudohypoaldosteronism type 1 (PHA-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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