Thermo Fisher Scientific PPP3CC Polyclonal Antibody
PPP3CC 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체이며, 1 mg/mL 농도. 세포질 및 미토콘드리아에서 발현되는 PPP3CC 단백질 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within human PPP3CC (aa 1–200) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913373 |
Product Specific Information
- Positive Control: HepG2 cell lysate, mouse hippocampus tissue lysate, HepG2, mouse testis tissue
- Subcellular Location: Cytosol, presynaptic cytosol, mitochondrion, calcineurin complex, cytoplasm, glutamatergic synapse
Target Information
Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biological activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of sperm is thought to be controlled by cAMP-dependent phosphorylation, and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme consists of catalytic and regulatory subunits of approximately 60 and 18 kDa, respectively. At least three genes—calcineurin A-alpha, calcineurin A-beta, and calcineurin A-gamma (CALNA3)—encode the catalytic subunit. These genes are identified in humans, mice, and rats, showing high conservation between species (90–95% amino acid identity).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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