Thermo Fisher Scientific TNFRSF14 (HVEM) Chimeric Recombinant Rabbit Monoclonal Antibody (HMHV-1B18)
HVEM(TNFRSF14) 특이적 재조합 토끼 단클론 항체로, Western blot, ICC/IF, Flow cytometry 등 다양한 실험에 사용 가능. HEK293 세포에서 발현된 IgG kappa 형태이며 Protein A로 정제됨. 연구용으로 면역 반응 및 바이러스 진입 메커니즘 분석에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.01 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 1:100 |
| Immunoprecipitation (IP) | Assay-dependent |
| Functional Assay | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HMHV-1B18 |
| Immunogen | This antibody was raised by immunising Armenian hamsters with mouse HVEM:Fc fusion protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074573 |
Product Specific Information
This antibody is specific for Herpes Virus Entry Mediator (HVEM, TR2), a type I transmembrane protein of the TNF-receptor superfamily.
Target Information
TNFRSF14 is a member of the TNF-receptor superfamily and acts as a cellular mediator of herpes simplex virus (HSV) entry. HSV envelope glycoprotein D (gD) binds to TNFRSF14 as part of the viral entry mechanism.
The cytoplasmic region of TNFRSF14 interacts with TRAF family members, mediating signal transduction pathways that activate immune responses.
Activation of TNFRSF14 in T cells promotes proliferation and cytokine production, enhancing inflammation and CTL-mediated tumor immunity.
Multiple alternatively spliced transcript variants have been described, though some full-length forms remain undetermined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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