Thermo Fisher Scientific IFNAR1 Monoclonal Antibody (A5-A3)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

A5-A3

Immunogen

Recombinant protein within human IFNAR1 aa 28-127 (Extracellular) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IFNAR1,uniProtId:P17181-1,ncbiNodeId:9606,antigenRange:28-127,antigenLength:557,antigenImageFileName:MA5-42390_IFNAR1_P17181-1_House_mouse.svg,antigenImageFileNamePDP:MA5-42390_IFNAR1_P17181-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 50% glycerol, 0.2% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2911531

Product Specific Information

Positive Control: K562, A431, Siha, mouse brain tissue lysate, NCCIT, SHUG-44, human lung tissue, human skin tissue, human colon tissue.

Subcellular Location: Endosome. Cell membrane.

Target Information

Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron,2001, Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-& Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.