Thermo Fisher Scientific IGF2BP3 Monoclonal Antibody (4-C2-5)
IGF2BP3 단백질을 인식하는 Thermo Fisher Scientific의 단일클론 항체로, Western blot 및 유세포분석에 적합합니다. 인간 및 생쥐 시료에 반응하며, Protein G로 정제된 액상 형태입니다. 4°C 단기 보관, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4-C2-5 |
| Immunogen | Recombinant protein within human IMP3 aa 350–579 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911535 |
Product Specific Information
- Positive Control: 293T, PANC-1
- Subcellular Location: Nucleus
Target Information
Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family. It is expressed during embryogenesis and in certain malignancies.
IMP-3 is expressed in malignant melanoma but not in benign nevi, even with dysplastic features. It shows higher expression in melanomas than in Spitz nevi, and in metastatic melanomas compared to thin melanomas. IMP-3 may be involved in melanoma progression and regulation of tumor biological behavior.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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