Thermo Fisher Scientific TMEM16B Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunocytochemistry (ICC/IF)

1:50-1:100

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ANO2 (NP_0012655261) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TMEM16B,uniProtId:Q9NQ90-1,ncbiNodeId:9606,antigenRange:1-200,antigenLength:1003,antigenImageFileName:PA5-92044_TMEM16B_Q9NQ90-1_Rabbit.svg,antigenImageFileNamePDP:PA5-92044_TMEM16B_Q9NQ90-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.28 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806363

Product Specific Information

Immunogen sequence: MPEDIPLLPG SPRRLSPQAG SRGGQGPKHG QQCLKMPGPR APGLQGGSNR DPGQPCGGES TRSSSVINNY LDANEPVSLE ARLSRMHFHD SQRKVDYVLA YHYRKRGVHL AQGFPGHSLA IVSNGETGKE PHAGGPGDIE LGPLDALEEE RKEQREEFEH NLMEAGLELE KDLENKSQGS IFVRIHAPWQ VLAREAEFLK; Positive Samples: Mouse brain; Cellular Location: Cell membrane, Multi-pass membrane protein

Target Information

Calcium-activated chloride channels (CaCC) are present in many cell types and mediate physiological functions such as epithelial secretion, sensory signal transduction, and smooth muscle contraction. Subunits of these CaCCs include the transmembrane proteins TMEM16A and TMEM16B. TMEM16B is predicted to have eight transmembrane domains with both the amino and carboxy termini in the cytoplasm and is expressed in several tissues including olfactory sensory neurons as well as photoreceptors in mammalian retina. Like TMEM16A, TMEM16B is thought to form at least part of CaCCs but has different biophysical characteristics such as voltage dependence and unitary conductance.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.