Thermo Fisher Scientific TGF beta-2 Polyclonal Antibody
TGF beta-2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot과 ELISA에 적합합니다. Human, Mouse, Rat 시료에 반응하며, Affinity Chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 -20°C에서 안정적입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 20–160 of human TGFB2 (NP_001129071.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.41 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806362 |
Product Specific Information
- Positive Samples: A-549, Mouse heart
- Immunogen sequence:
SLSTCSTLDM DQFMRKRIEA IRGQILSKLK LTSPPEDYPE PEEVPPEVIS IYNSTRDLLQ EKASRRAAAC ERERSDEEYY AKEVYKIDMP PFFPSETVCP VVTTPSGSVG SLCSRQSQVL CGYLDAIPPT FYRPYFRIVR F
Target Information
Transforming Growth Factor (TGF) betas mediate many cell-to-cell interactions that occur during embryonic development. Three TGF betas have been identified in mammals: TGF beta 1, TGF beta 2, and TGF beta 3.
Each is synthesized as a precursor protein, cleaved to yield a 112 amino acid polypeptide associated with the latent portion of the molecule.
TGF beta polypeptides are multifunctional, influencing cell proliferation, differentiation, and other cellular functions. Both transformed and nonneoplastic tissues release transforming growth factors, and nearly all mammalian cells possess specific TGF receptors.
TGF beta can stimulate or inhibit proliferation depending on cell type — generally stimulating mesenchymal cells while inhibiting epithelial or neuroectodermal cells.
TGF beta 1, TGF beta 2, and TGF beta 1.2 are similar in biological activity but differ slightly in receptor binding.
TGF beta 2 is produced by many cell types and is found in high concentrations in porcine platelets and mammalian bone. Latent TGF beta 2 is the predominant isoform in body fluids such as amniotic fluid, breast milk, and ocular humors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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