Thermo Fisher Scientific c-MAF Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Positive Control: HepG2
• Predicted Reactivity: Mouse (100%), Rat (99%), Chicken (91%), Bovine (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

c-maf is the cellular counterpart of oncogenic v-maf belonging to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain is involved in interaction with LRPICD.
There are two forms of human c-maf mRNA: c-maf-long and c-maf-short. It is identified in the genome of the acute transforming avian retrovirus AS42.
c-maf targets include IL-4 in Th2 cells, crystalline genes in lens fiber cells, insulin gene in islet, p53, and L7, exerting transcriptional roles through binding to Maf recognition element (MARE).
It regulates Th2 differentiation and lineage-specific hematopoiesis and acts as a transcription factor for IL-10 gene expression in LPS-activated macrophages.
Chromosomal aberration involving maf is found in some forms of multiple myeloma. It is expressed in myeloma cell lines and resting monocytes/macrophages.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.