Thermo Fisher Scientific c-MAF Polyclonal Antibody
Thermo Fisher Scientific의 c-MAF Polyclonal Antibody는 인간 및 마우스에 반응하며 Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제된 고품질 항체로, PBS 및 20% 글리세롤 버퍼에 보관됩니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PA578051
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human c-Maf (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2735540 |
Product Specific Information
- Positive Control: HepG2
- Predicted Reactivity: Mouse (100%), Rat (99%), Chicken (91%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
c-maf is the cellular counterpart of oncogenic v-maf belonging to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain is involved in interaction with LRPICD.
There are two forms of human c-maf mRNA: c-maf-long and c-maf-short. It is identified in the genome of the acute transforming avian retrovirus AS42.
c-maf targets include IL-4 in Th2 cells, crystalline genes in lens fiber cells, insulin gene in islet, p53, and L7, exerting transcriptional roles through binding to Maf recognition element (MARE).
It regulates Th2 differentiation and lineage-specific hematopoiesis and acts as a transcription factor for IL-10 gene expression in LPS-activated macrophages.
Chromosomal aberration involving maf is found in some forms of multiple myeloma. It is expressed in myeloma cell lines and resting monocytes/macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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