Thermo Fisher Scientific MCM4 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Positive Control: Jurkat, Raji, NCI-H929, 293T, A431, HeLa, HepG2, Neuro 2A, C8D30, NIH-3T3, Raw264.7, C2C12
• Predicted Reactivity: Rat (99%), Zebrafish (87%), Xenopus laevis (92%), Rhesus Monkey (99%), Bovine (97%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) essential for the initiation of eukaryotic genome replication. The hexameric MCM complex is a key component of the pre-replication complex (pre_RC) and is involved in replication fork formation and recruitment of DNA replication-related proteins. The MCM complex containing MCM2, 4, 6, and 7 exhibits DNA helicase activity and functions as a DNA unwinding enzyme. Phosphorylation by CDC2 kinase reduces helicase activity and chromatin binding. This gene is located on chromosome 8 near PRKDC/DNA-PK, a DNA repair kinase. Alternatively spliced transcript variants encoding the same protein have been reported.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.