Thermo Fisher Scientific mGluR1 Polyclonal Antibody
Rabbit polyclonal antibody against mGluR1 for detection in human, mouse, and rat samples. Validated for WB, IHC, and ICC applications. Supplied in liquid form at 1 mg/mL, affinity purified, and suitable for long-term storage at -20°C. For research use ...
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues S(1159)–L(1171) of the human GluR1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store refrigerated at 2–8°C for up to 3 months; for long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2294910 |
Product Specific Information
PA1-4516 detects Metabotropic Glutamate Receptor 1 (mGluR1) in human, rat, and mouse samples.
Validated for use in Western blot and Immunohistochemistry applications.
The immunogen is a synthetic peptide corresponding to residues 1159–1171 of the human GluR1 protein.
Store at 4°C for up to 3 months or at -20°C for longer periods. Avoid repeated freeze/thaw cycles.
Target Information
Glutamate is the primary excitatory neurotransmitter in the brain. Traditionally, it was known to act on ligand-gated receptor channels such as NMDA, AMPA, and kainate receptors involved in fast excitatory synaptic transmission.
Recent findings show that glutamate also regulates enzymes producing second messengers via G-protein-coupled receptors known as metabotropic glutamate receptors (mGluRs).
- Group I receptors (mGluR1a, mGluR5): Stimulate phospholipase C, increasing phosphoinositide turnover and calcium release.
- Group II and III receptors (mGluR2, mGluR3): Inhibit adenylyl cyclase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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