Thermo Fisher Scientific CD127/IL-7R alpha Recombinant Rabbit Monoclonal Antibody (BLR177J)
Recombinant rabbit monoclonal antibody targeting human CD127/IL-7Rα. Western blot, IHC, IP에 사용 가능. 고순도 액상 형태로 제공되며, 4°C 보관. 면역조직화학에서 citrate buffer(pH 6.0) 전처리 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunoprecipitation (IP) | 6 µL/mg of lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR177J |
| Immunogen | Recombinant protein representing the extracellular domain of Human Interleukin-7 receptor subunit alpha (residues 21–236) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry: Epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
CD127 (Interleukin-7 receptor alpha, IL-7Rα) is a glycoprotein involved in the regulation of lymphopoiesis. The active receptor is a heterodimer composed of an alpha and a gamma chain. The gamma(c) chain, also shared with the interleukin-2 receptor, mediates signal transduction, while the alpha chain determines specific signaling events through cytoplasmic signaling molecule interactions.
CD127 promotes proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4⁺ and CD8⁺ T cells. Dysfunctions in CD127 are associated with severe combined immunodeficiency, including T cell negative/B cell negative/NK positive forms.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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