Thermo Fisher Scientific iNOS Recombinant Rabbit Monoclonal Antibody (BLR181J)
iNOS 단백질을 인식하는 Thermo Fisher의 재조합 토끼 단일클론 항체로, WB, ICC/IF, IP에 적합. HEK293F 발현 시스템 사용, 고순도 정제된 액상 형태. FFPE 조직에서 citrate buffer pH 6.0을 이용한 epitope retrieval 권장. 연구용 전용 제품.
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Thermo Fisher Scientific iNOS Recombinant Rabbit Monoclonal Antibody (BLR181J)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Immunoprecipitation (IP) | 6 µL/mg of lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR181J |
| Immunogen | Peptide representing region between residue 1094 and C-terminus (1144) of mouse inducible nitric oxide synthase (iNOS) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunocytochemistry: Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
iNOS (Inducible Nitric Oxide Synthase) is an enzyme that produces nitric oxide (NO), a gaseous free radical involved in vasorelaxation, neurotransmission, and cytotoxicity.
NO synthesis is mediated by NOS family members, including:
- nNOS (type I) – neuronal NOS
- eNOS (type III) – endothelial NOS
- iNOS (type II) – inducible NOS
iNOS is expressed in liver and inducible by lipopolysaccharides and cytokines (IFN-γ, TNF, IL-1, IL-2).
It catalyzes the oxidation of L-arginine to L-citrulline and NO, containing calmodulin, NADPH, FAD, and FMN binding domains.
Found in macrophages, hepatocytes, synoviocytes, and smooth muscle cells.
Cytokine induction leads to increased iNOS mRNA, protein, and activity, resulting in sustained NO production.
Dysfunction of iNOS is associated with diseases such as achalasia and impotence.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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