Thermo Fisher Scientific TNFRSF14 Monoclonal Antibody (OTI1F12), TrueMAB
인간 TNFRSF14 단백질을 인식하는 Mouse IgG1 단일클론 항체. Western blot에 최적화되어 있으며, 동결건조 형태로 제공. 재구성 후 1 mg/mL 농도로 사용 가능. 면역반응 및 HSV 진입 연구에 유용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 39–283 of human TNFRSF14 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
TNFRSF14 is a member of the TNF receptor superfamily and functions as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV envelope glycoprotein D (gD) to TNFRSF14 facilitates viral entry. The cytoplasmic region interacts with TRAF family members to activate immune signaling pathways. Activation in T cells stimulates proliferation and cytokine production, enhancing CTL-mediated tumor immunity. TNFRSF14 variants may serve as potential targets for immune response modulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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