Thermo Fisher Scientific SDHB Monoclonal Antibody (OTI2A1), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Complex II of the mitochondrial respiratory chain is involved in the oxidation of succinate and electron transfer from FADH to CoQ.
It consists of four nuclear-encoded subunits located in the mitochondrial inner membrane.
The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters that form the enzyme’s iron-sulfur centers.
Mutations in this gene are associated with paragangliomas and pheochromocytoma, linking mitochondrial dysfunction to tumorigenesis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.