Thermo Fisher Scientific ACVRL1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1 µg/mL

Immunoprecipitation (IP)

• Tested Dilution: Assay-Dependent

Product Specifications

Product Specific Information

• In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant mouse ALK-1 is observed, and less than 1% cross-reactivity with recombinant human Activin RIA and Activin RIB is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.
• Endotoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Target Information

Activin A receptor type II-like 1 (ACVRL1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. Similar to other type I receptors, ACVRL1 has a conserved serine-threonine kinase subdomain, a glycine- and serine-rich GS domain preceding the kinase domain, and a short C-terminal tail.
Mutations in ACVRL1 are associated with hemorrhagic telangiectasia type 2 and have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by abnormal bone formation in soft tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)