Thermo Fisher Scientific ACVRL1 Polyclonal Antibody
인간 ACVRL1 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot 및 Immunoprecipitation에 사용 가능하며, 높은 특이성과 낮은 교차 반응성을 가짐. 항원 친화 크로마토그래피로 정제된 동결건조 형태로 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1 µg/mL
Immunoprecipitation (IP)
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human ALK-1 (Asp22–Gln118) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608871 |
Product Specific Information
- In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant mouse ALK-1 is observed, and less than 1% cross-reactivity with recombinant human Activin RIA and Activin RIB is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
Activin A receptor type II-like 1 (ACVRL1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. Similar to other type I receptors, ACVRL1 has a conserved serine-threonine kinase subdomain, a glycine- and serine-rich GS domain preceding the kinase domain, and a short C-terminal tail.
Mutations in ACVRL1 are associated with hemorrhagic telangiectasia type 2 and have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by abnormal bone formation in soft tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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