Thermo Fisher Scientific KCNQ5 Polyclonal Antibody
KCNQ5 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간 및 랫드 시료에서 반응. Western blot 등 다양한 응용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/BSA buffer에 보관. 연구용으로만 사용.
- 카탈로그번호
- PA1941
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:250 | - |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunocytochemistry (ICC/IF) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues C(880)-K-A-G-E-S-T-D-A-L-S-L-P-H-V-K-L-K(897) of human KCNQ5 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2131842 |
Product Specific Information
PA1-941 detects KCNQ5 from rat and human samples. This antibody is specific for KCNQ5 and does not detect KCNQ1, KCNQ2, KCNQ3, or KCNQ4.
PA1-941 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~125 kDa band representing KCNQ5 from rat brain extract.
The PA1-941 immunizing peptide corresponds to amino acid residues 880–897 from human KCNQ5.
Target Information
KCNQs are members of the voltage-dependent non-inactivating potassium channel family. There are five known KCNQs (KCNQ1–5) found in the central nervous system.
KCNQ3 and KCNQ5 form heteromultimers that substantially increase the M-current, which regulates neuronal excitability and synaptic responsiveness.
Mutations in these proteins have been associated with disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain, and epilepsy.
Voltage-dependent potassium channels regulate the resting membrane potential and modulate excitability in electrically active cells. These channels are typically tetrameric and can interact with auxiliary subunits that modify current properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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