Thermo Fisher Scientific KCNQ5 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

PA1-941 detects KCNQ5 from rat and human samples. This antibody is specific for KCNQ5 and does not detect KCNQ1, KCNQ2, KCNQ3, or KCNQ4.
PA1-941 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~125 kDa band representing KCNQ5 from rat brain extract.
The PA1-941 immunizing peptide corresponds to amino acid residues 880–897 from human KCNQ5.

Target Information

KCNQs are members of the voltage-dependent non-inactivating potassium channel family. There are five known KCNQs (KCNQ1–5) found in the central nervous system.
KCNQ3 and KCNQ5 form heteromultimers that substantially increase the M-current, which regulates neuronal excitability and synaptic responsiveness.
Mutations in these proteins have been associated with disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain, and epilepsy.
Voltage-dependent potassium channels regulate the resting membrane potential and modulate excitability in electrically active cells. These channels are typically tetrameric and can interact with auxiliary subunits that modify current properties.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.