Thermo Fisher Scientific KCNQ5 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:250

-

Immunohistochemistry (IHC)

-

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

-

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Rat

Published species

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues C(880) K A G E S T D A L S L P H V K L K(897) of human KCNQ5 protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:KCNQ5,uniProtId:Q9NR82-1,ncbiNodeId:9606,antigenRange:880-897,antigenLength:932,antigenImageFileName:PA1-941_KCNQ5_Q9NR82-1_Rabbit.svg,antigenImageFileNamePDP:PA1-941_KCNQ5_Q9NR82-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2131842

Product Specific Information

PA1-941 detects the KCNQ5 from rat and human samples. This antibody is specific for KCNQ5 and does not detect KCNQ1, KCNQ2, KCNQ3 or KCNQ4.

PA1-941 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~125 kDa band representing KCNQ5 from rat brain extract.

The PA1-941 immunizing peptide corresponds to amino acid residues 880-897 from human KCNQ5.

Target Information

KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system. Studies have shown that KCNQ3 and KCNQ5 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy. Voltage-dependent potassium channels are key regulators of the resting membrane potential and modulate the excitability of electrically active cells. The channels are usually tetrameric and can interact with auxiliary subunits that enhance or modify currents mediated by the pore-forming subunits.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.