Thermo Fisher Scientific P-Selectin Recombinant Superclonal Antibody (3HCLC)

Applications

• Western Blot (WB): 1:500–1:5,000
• Immunocytochemistry (ICC/IF): 1:100–1:1,000

Product Specifications

Product Specific Information

This antibody is predicted to react with non-human primate, mouse, and rat based on sequence homology.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They combine multiple recombinant monoclonal antibodies, offering the sensitivity of polyclonal antibodies and the specificity and consistency of monoclonal antibodies.
Each lot contains a known mixture of light and heavy chains, eliminating biological variability seen in traditional polyclonal antibody production.
Formerly called “Recombinant polyclonal antibody”, now rebranded as “Recombinant Superclonal™ antibody”. The physical product and performance remain unchanged.

Target Information

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type I transmembrane glycoprotein involved in cell rolling regulation.
It is stored in Weibel-Palade bodies of endothelial cells and α-granules of platelets, translocating rapidly to the cell surface upon activation by thrombin, histamine, or other stimuli.
P-selectin mediates interactions between activated endothelial cells or platelets and leukocytes, playing a critical role in adhesion processes.
It binds sialylated Lewis carbohydrate antigens on neutrophils and monocytes in a calcium-dependent manner.
Clinically, P-selectin helps distinguish heparin-induced thrombocytopenia with and without thrombosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.