Thermo Fisher Scientific Phospho-SMO (Ser611, Ser615) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Positive Samples: Jurkat
• Immunogen sequence: SADVS

Target Information

Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 amino acids. It has seven transmembrane domains, four glycosylation sites, and a putative extracellular amino terminus.
Smoothened, activated by β-Arrestin 2 and GRK2, acts as a receptor for Sonic hedgehog (Shh) and is a positive regulator of the hedgehog signaling pathway along with the patched protein (PTCH). It regulates vertebrate developmental processes, cellular proliferation, and differentiation via activation of the transcription factor Gli.
Mutations in Smoothened are associated with sporadic basal cell carcinoma of the skin. Expression is observed broadly in the heart and brain.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.