Thermo Fisher Scientific Phospho-Aurora A/B/C (Thr288, Thr232, Thr198) Polyclonal Antibody
Aurora A/B/C 단백질의 인산화 형태(Thr288, Thr232, Thr198)를 인식하는 Rabbit Polyclonal 항체로, Western blot 및 ELISA에 적합합니다. 세포 분열 및 유사분열 조절 관련 연구에 사용되며, 고순도 Affinity 정제 및 안정한 PBS/glycerol buffer로 보관됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around T288 of human AURKA/AURKB/AURKC (NP_003591.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.33 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901863 |
Product Specific Information
- Positive Samples: HeLa
- Immunogen sequence: RTTLC
Target Information
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a key regulator of mitosis. The CPC ensures correct chromosome alignment and segregation, and is required for chromatin-induced microtubule stabilization and spindle assembly.
AURKB phosphorylates CPC subunits such as BIRC5/survivin, CDCA8/borealin, and INCENP, enhancing its own activity. It also phosphorylates substrates including CENPA, DES, KIF2C, NSUN2, RACGAP1, SEPT1, VIM, GSG2, and histone H3 (Ser-10, Ser-28).
AURKB is essential for kinetochore localization of BUB1 and SGOL1 and negatively regulates p53/TP53 transcriptional activity. It acts as a key regulator of active promoters in resting B- and T-lymphocytes.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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