Thermo Fisher Scientific Phospho-Tau (Thr231) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Samples: Mouse brain
• Immunogen sequence: VRTPP

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, functioning as a linker protein. Tau localization determines axonal polarity. Short isoforms contribute to cytoskeletal plasticity, while longer isoforms aid stabilization.
In its hyper-phosphorylated form, Tau forms paired helical filaments (PHF), a major component of neurofibrillary tangles in Alzheimer’s disease (AD). Hyper-phosphorylation impairs microtubule binding, leading to neuronal degeneration. Multiple kinases such as GSK-3β, PKA, cdk5, and casein kinase II phosphorylate Tau. Abnormal Tau phosphorylation is also observed in Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.