Thermo Fisher Scientific Phospho-(Ser/Thr) ATM + ATR Substrate Polyclonal Antibody
ATM 및 ATR 인산화 기질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 ELISA에 사용 가능. 모든 종에 반응하며, 1.65 mg/mL 농도의 액상 형태. Affinity chromatography로 정제되어 높은 특이성과 재현성을 제공. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | All |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence containing phosphorylated S & T |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.65 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901861 |
Product Specific Information
Positive Samples: Jurkat, NIH/3T3, C6
Target Information
Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3-related kinase (ATR) are related kinases that regulate cell cycle checkpoints and DNA repair. Identified substrates for ATM include p53, p95/NBS1, MDM2, Chk2, BRCA1, CtIP, 4E-BP1, and Chk1.
The essential requirement for the substrates of ATM/ATR is S/T*Q. Hydrophobic amino acids at positions -3 and -1, and negatively charged amino acids at position +1 are positive determinants for substrate recognition by these kinases. Positively charged residues surrounding the S/T*Q are negative determinants for substrate phosphorylation. The complex phenotype of AT cells suggests that additional substrates likely exist.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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