Thermo Fisher Scientific MRE11 Monoclonal Antibody (F.519.4)
MRE11 단백질을 표적하는 토끼 단클론 항체로, Western blot, IHC 및 IP에 적합합니다. MRN 복합체 연구에 유용하며, 고순도 친화 크로마토그래피로 정제되었습니다. 인간 시료에 반응하며, 액상 형태로 -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:500 |
| Immunoprecipitation (IP) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F.519.4 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Lys496 of human Mre11A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10981293 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
MRE11 (double-strand break repair protein MRE11) is a component of the MRN complex, which plays a central role in double-strand break repair, DNA recombination, maintenance of telomere integrity, and meiosis. The complex possesses single-stranded endonuclease activity and double-strand-specific 3'-5' exonuclease activity provided by MRE11. RAD50 binds DNA ends and holds them in close proximity. Mutations in the MRE11 gene can result in ataxia-telangiectasia-like disorder 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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