Thermo Fisher Scientific Ido Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing.
Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.

A BLAST analysis suggests cross-reactivity with human, rat, and mouse based on 100% sequence homology. Cross-reactivity with IDO from other sources has not been determined.

Target Information

IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules such as tryptophan, serotonin, and melatonin.
This reaction initiates the production of biologically active metabolites known as kynurenines.

IDO1 is widely expressed in human tissues, macrophages, and dendritic cells. During inflammation, interferons (IFNs) induce IDO1 expression, contributing to antimicrobial defense mechanisms.
Tryptophan degradation by IDO1 inhibits the growth of viruses, bacteria, and parasites.
IDO1 also plays critical roles in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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