Thermo Fisher Scientific Phospho-14-3-3 beta (Ser58) Polyclonal Antibody
Phospho-14-3-3 beta (Ser58) 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot 및 IHC에 적합. 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제, -20°C 보관. 신호전달 및 세포주기 연구용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- Publications: View 2 publications
Immunohistochemistry (IHC)
- Tested Dilution: 1:500
- Publications: View references
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser58 of rat YWHAB conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_557394 |
Product Specific Information
This antibody is predicted to react with bovine, canine, chicken, mouse, non-human primate, sheep, Xenopus, and zebrafish based on 100% sequence homology.
It is specific for the ~29 kDa 14-3-3 protein phosphorylated at Ser58. Immunolabeling is blocked by preadsorption with the immunogen protein.
Target Information
14-3-3 is a family of acidic, soluble proteins highly conserved across species from yeast to mammals, expressed in all eukaryotic cells.
Seven isoforms (beta, gamma, epsilon, eta, zeta, sigma, tau/theta) are encoded by distinct genes and form homo- and heterodimeric cup-shaped structures.
14-3-3 proteins interact with more than 100 binding partners and regulate key proteins involved in signal transduction, cell cycle, transcriptional control, cell proliferation, apoptosis, and ion channel physiology.
This protein is abundantly expressed in the brain and detected in cerebrospinal fluid of patients with various neurological disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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