Thermo Fisher Scientific HRD1 Polyclonal Antibody
HRD1 단백질 검출용 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, ICC에 적합하며 다양한 종(햄스터, 인간, 마우스)에 반응. 항원 친화 크로마토그래피로 정제된 액상 항체로 -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to an internal portion of the human protein (within residues 300–400). [UniProt Q96PK3] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Whole serum, PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2199833 |
Product Specific Information
- Suggested positive control: 293T, INS-1, and MIN6 cell lysates, antigen standard for SYVN1 (transient overexpression lysate).
Target Information
HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney, and skeletal muscle. Synoviolin/Hrd1, expressed in rheumatoid synovium, has been reported as a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects. HRD1 contains one ring-type zinc finger.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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