Thermo Fisher Scientific RANKL (soluble) Monoclonal Antibody, PeproTech

Applications

ELISA (ELISA)

• Tested Dilution: 1.0–2.0 µg/mL
• Publications: 참고 문헌 보기

Dot blot (DB)

• Tested Dilution: –
• Publications: 참고 문헌 보기

Product Specifications

Product Specific Information

Amino Acid Sequence of Recombinant Protein:
MEKAMVDGSW LDLAKRSKLE AQPFAHLTIN ATDIPSGSHK VSLSSWYHDR GWAKISNMTF SNGKLIVNQD GFYYLYANIC FRHHETSGDL ATEYLQLMVY VTKTSIKIPS SHTLMKGGST KYWSGNSEFH FYSINVGGFF KLRSGEEISI EVSNPSLLDP DQDATYFGAF KVRDID.

Preparation:
Produced in BALB/c × ICR F1 mice immunized with highly pure Recombinant Human sRANK Ligand.
Anti-Human sRANK Ligand-specific antibody was purified from cell culture by Protein G affinity chromatography.

Target Information

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation.
It also acts as a dendritic cell survival factor and regulates T cell-dependent immune responses.
Activation of T cells induces expression of this gene, increasing osteoclastogenesis and bone loss.
The protein activates antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and TRAF6, suggesting a role in apoptosis regulation.
Knockout studies in mice show severe osteopetrosis, lack of osteoclasts, and defects in T/B lymphocyte differentiation and mammary gland development.
Two alternatively spliced transcript variants have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.