Thermo Fisher Scientific TRAIL (soluble) Monoclonal Antibody, PeproTech

Applications and Tested Dilutions

Product Specifications

Product Specific Information

AA Sequence of recombinant protein:
MRERGPQRVA AHITGTRGRS NTLSSPNSKN EKALGRKINS WESSRSGHSF LSNLHLRNGE LVIHEKGFYY IYSQTYFRFQ EEIKENTKND KQMVQYIYKY TSYPDPILLM KSARNSCWSK DAEYGLYSIY QGGIFELKEN DRIFVSVTNE HLIDMDHEAS FFGAFLVG.

Preparation:
Produced in BALB/c mice immunized with highly pure Recombinant Human sTRAIL/Apo2L. Anti-Human sTRAIL/Apo2L-specific antibody was purified from cell culture by Protein G affinity chromatography.

Target Information

TRAIL is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. It preferentially induces apoptosis in transformed and tumor cells while sparing normal cells. TRAIL interacts with multiple TNF receptor superfamily members, including TRAILR1 (DR4), TRAILR2 (DR5), TRAILR3 (DcR1), TRAILR4 (DcR2), and possibly OPG.
Binding of TRAIL to its receptors activates signaling pathways such as MAPK8/JNK, caspase 8, and caspase 3, leading to apoptosis and NF-kB activation. TRAIL is a type II membrane protein expressed in various human tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.