Thermo Fisher Scientific TECK Monoclonal Antibody, PeproTech

Applications

Western Blot (WB)

• Tested Dilution: 0.25–0.50 µg/mL

ELISA

• Tested Dilution: 2.0–4.0 µg/mL

Product Specifications

Product Specific Information

AA Sequence of recombinant protein:
QGVFEDCCLA YHYPIGWAVL RRAWTYRIQE VSGSCNLPAA IFYLPKRHRK VCGNPKSREV QRAMKLLDAR NKVFAKLHHN MQTFQAGPHA VKKLSSGNSK LSSSKFSNPI SSSKRNVSLL ISANSGL

Preparation:
Produced in BALB/c mice immunized with highly pure Recombinant Human TECK (CCL25). Anti-Human TECK (CCL25)-specific antibody was purified from cell culture by Protein G affinity chromatography.

Target Information

Chemokines are likely to play an important role in regulating the trafficking of developing T cells within the thymus. Chemokine C-C thymus expressed chemokine (TECK), also designated chemokine ligand 25 (CCL25), small inducible cytokine A25, chemokine b-15 or CK b-15, is expressed predominantly in thymic dendritic cells, thymic epithelial cells and in the small intestine.
TECK, a CCR9 ligand, has suppressive activity against immature subsets of myeloid progenitors which have been stimulated to proliferate by multiple growth factors. TECK delivers signals through CCR9, which is important for the navigation of developing thymocytes.
Bone marrow pre-pro-B cells and cells capable of generating pro-B colonies in the presence of interleukin-7 and Flt-3 ligand migrate to TECK, a response lost in later stages of B cell development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.