Thermo Fisher Scientific LIME1 Monoclonal Antibody (OTI7A9), TrueMAB
LIME1 단백질을 인식하는 Mouse Monoclonal Antibody (Clone OTI7A9). Western Blot에 최적화되어 있으며 Human 시료에 반응. Lyophilized 형태로 제공되며, 재구성 후 1 mg/mL 농도 유지. 연구용으로 T세포 신호전달 연구에 적합.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7A9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 30–295 of human LIME1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with a basic cytoplasmic domain expressed by T cells. Upon ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck, Fyn, and the negative regulator Csk.
Csk-mediated phosphorylation of Lck associated with LIME can increase enzymatic activity, making LIME a positive regulator of TCR-dependent T cell signaling, though it may also mediate inhibitory signals under certain conditions.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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