Thermo Fisher Scientific ATP1B1 Monoclonal Antibody (464.8 (aka 8A))

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000
• View 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-Dependent
• View publications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:500–1:1,000
• View publications

Product Specifications

Product Specific Information

This antibody does not react with mouse samples.

Target Information

The protein encoded by this gene belongs to the family of Na⁺/K⁺ and H⁺/K⁺ ATPases beta chain proteins, and to the subfamily of Na⁺/K⁺-ATPases.
Na⁺/K⁺-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane.
These gradients are essential for osmoregulation, sodium-coupled transport of various molecules, and electrical excitability of nerve and muscle.
This enzyme is composed of two subunits: a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta).
The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
The glycoprotein subunit of Na⁺/K⁺-ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit.
Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.