Thermo Fisher Scientific CLCC1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 302-501 of human CLCC1 (NP_055942.1). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CLCC1,uniProtId:Q96S66-1,ncbiNodeId:9606,antigenRange:302-501,antigenLength:551,antigenImageFileName:PA5-120569_CLCC1_Q96S66-1_Rabbit.svg,antigenImageFileNamePDP:PA5-120569_CLCC1_Q96S66-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.43 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914141

Product Specific Information

Positive test controls include: U-87MG, 22Rv1, Mouse spleen.

Immunogen sequence: GAGKSVHVLR HIGGPESEPP QALRPRDRRR QEEIDYRPDG GAGDADFHYR GQMGPTEQGP YAKTYEGRRE ILRERDVDLR FQTGNKSPEV LRAFDVPDAE AREHPTVVPS HKSPVLDTKP KETGGILGEG TPKESSTESS QSAKPVSGQD TSGNTEGSPA AEKAQLKSEA AGSPDQGSTY SPARGVAGPR GQDPVSSPCG

Target Information

Neurofibromin is a member of the GTPase-activating (GAP) class of proteins. These proteins enhance the GTPase activity of signaling G-Proteins like Ras. The NF1 gene is also classified as a tumor suppressor gene, and many studies have shown that mutations at the NF1 locus produce neurofibromas, rhabdomyosarcomas, leimyosarcomas, mental retardation and memory deficiency. Neurofibromin has also been associated with the intermediated filaments of the cytoskeleton. NF1 is expressed at its highest levels during periods of desmosome formation and mutations of NF1 produce variable cell sizes and morphologies.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.