
Thermo Fisher Scientific CLCC1 Polyclonal Antibody
Thermo Fisher Scientific의 CLCC1 Polyclonal Antibody는 인간 및 생쥐 시료에서 CLCC1 단백질을 검출하기 위한 다클론 항체입니다. Western blot, IHC, ELISA에 적합하며 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 302–501 of human CLCC1 (NP_055942.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.43 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914141 |
Product Specific Information
Positive test controls include: U-87MG, 22Rv1, Mouse spleen.
Immunogen sequence:
GAGKSVHVLR HIGGPESEPP QALRPRDRRR QEEIDYRPDG GAGDADFHYR GQMGPTEQGP YAKTYEGRRE ILRERDVDLR FQTGNKSPEV LRAFDVPDAE AREHPTVVPS HKSPVLDTKP KETGGILGEG TPKESSTESS QSAKPVSGQD TSGNTEGSPA AEKAQLKSEA AGSPDQGSTY SPARGVAGPR GQDPVSSPCG
Target Information
Neurofibromin is a member of the GTPase-activating (GAP) class of proteins, which enhance the GTPase activity of signaling G-proteins like Ras. The NF1 gene functions as a tumor suppressor, and mutations at the NF1 locus are associated with neurofibromas, rhabdomyosarcomas, leiomyosarcomas, mental retardation, and memory deficiency. Neurofibromin has been linked to cytoskeletal intermediate filaments and is highly expressed during desmosome formation, with NF1 mutations causing variable cell sizes and morphologies.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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