Thermo Fisher Scientific JAB1 Polyclonal Antibody
JAB1 단백질을 인식하는 Rabbit Polyclonal 항체로 Western Blot 및 ELISA에 사용 가능. Human, Mouse, Rat 반응성. Affinity Chromatography로 정제된 액상 형태이며, PBS/glycerol buffer에 보관. 세포질 및 핵 등 다양한 세포 위치에서 발현된 JAB1 검출에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–334 of human JAB1/CSN5/COPS5 (NP_006828.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914142 |
Product Specific Information
Positive test controls include: U2OS, HeLa, MCF7, NIH/3T3, K-562, U-251MG, Mouse brain, Mouse heart, Rat testis.
The target is usually found in the following locations: Cytoplasm, Cytoplasmic vesicle, Nucleus, perinuclear region, secretory vesicle, synaptic vesicle.
Immunogen sequence:
MAASGSGMAQ KTWELANNMQ EAQSIDEIYK YDKKQQQEIL AAKPWTKDHH YFKYCKISAL
ALLKMVMHAR SGGNLEVMGL MLGKVDGETM IIMDSFALPV EGTETRVNAQ AAAYEYMAAY
IENAKQVGRL ENAIGWYHSH PGYGCWLSGI DVSTQMLNQQ FQEPFVAVVI DPTRTISAGK
VNLGAFRTYP KGYKPPDEGP SEYQTIPLNK IEDFGVHCKQ YYALEVSYFK SSLDRKLLEL
LWNKYWVNTL SSSSLLTNAD YTTGQVFDLS EKLEQSEAQL GRGSFMLGLE THDRKSEDKL
AKATRDSCKT TIEAIHGLMS QVIKDKLFNQ INISTarget Information
JAB-1 is a 38 kDa protein originally described as a coactivator for cJUN. It is present in a large protein complex called the "Signalosome," which plays a signaling role in mammalian cells. This complex is analogous to the COP9 complex in plants, important in light-mediated plant development. JAB-1 has been implicated in targeting proteins for degradation by the proteasome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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